Vincent Abubakar scored twice with Frank Zambo-Anguissa and Clinton Njie adding one each as the hosts for the next AFCON edition picked a comfortable, morale-boosting victory.
The hosts were offensive from the word to go with Jean Charles Castelletto and Christian Bassogog initiating some chances that were however not converted.
After knocking on the door without an answer, Cameroon finally broke the deadlock after 37 minutes when Aboubakar headed home after Bassogog’s initial effort was blocked.
Despite going down, The Mambas tried to give in a fight but couldn’t get past Andre Onana who kept a hawk-eyed guard to ensure the Indomitable Lionscarried their slim lead to the break.
Two minutes after halftime, they were 2-0 away when Aboubakar completed his brace when he picked up a backheel pass from Toko Ekambi before striking the ball at goal, a slight deflection taking it off keeper Pedro Frenque's sight.
With a two-goal cushion, Cameroon were more comfortable and played the ball with ease. They would go 3-0 up in the 58th minute when Anguissa thumped home a bullet header off a Moumi Ngamaleu cross.
Mozambique grabbed one back with 15 minutes left on the clock when substitute Cumbane Kamo Kamo found the back of the net barely 10 minutes after coming on.
However, Cameroon would seal the victory 10 minutes to time Njie finishing off a Zambo-Anguissa pass.